The Ocular Glymphatic System and Idiopathic Intracranial Hypertension: Author Response to "Hypodense Holes and the Ocular Glymphatic System".

"Black Holes" and the Ocular Glymphatic System: Author Response to "The Glymphatic System: A New Player in Ocular Diseases?"

Pseudotumor Cerebri and Glymphatic Dysfunction

In contrast to virtually all organ systems of the body, the central nervous system was until recently believed to be devoid of a lymphatic system. The demonstration of a complex system of paravascular channels formed by the endfeet of astroglial cells ultimately draining into the venous sinuses has radically changed this idea. The system is subsidized by the recirculation of cerebrospinal fluid...

The Glymphatic Hypothesis of Glaucoma: A Unifying Concept Incorporating Vascular, Biomechanical, and Biochemical Aspects of the Disease

The pathophysiology of primary open-angle glaucoma is still largely unknown, although a joint contribution of vascular, biomechanical, and biochemical factors is widely acknowledged. Since glaucoma is a leading cause of irreversible blindness worldwide, exploring its underlying pathophysiological mechanisms is extremely important and challenging. Evidence from recent studies appears supportive ...

Paravascular Pathways in the Eye: Is There an 'Ocular Glymphatic System'?

In 2012, Iliff and colleagues proposed the existence of a paravascular transport system, which they termed the ‘glymphatic system.’ We propose that a similar system is present in the eye, the ‘Ocular Glymphatic System,’ and that this may be a key player in retinal diseases ranging from AMD to retinal vasculitis. Healthy brain function is dependent on the regulation of the volume and composition...

Glymphatic MRI in idiopathic normal pressure hydrocephalus

The glymphatic system has in previous studies been shown as fundamental to clearance of waste metabolites from the brain interstitial space, and is proposed to be instrumental in normal ageing and brain pathology such as Alzheimer's disease and brain trauma. Assessment of glymphatic function using magnetic resonance imaging with intrathecal contrast agent as a cerebrospinal fluid tracer has so ...